Selective Anticancer Effect of Phellinus Linteus on Epidermoid Cell Lines Studied by Atomic Force Microscopy: Anticancer Activity on A431 Cancer Cells and Low Toxicity on HaCat Normal Cells

The research on the morphological and mechanical properties of single cells has provided a crucial way understanding cellular physiology metabolism. In this study, selective anticancer effects Phellinus linteus A431 HaCat their were systematically investigated by atomic force microscopy (AFM). Notably, cell morphology micronano scale was observed under both physiological environment immobilization conditions. significant changes from flat to spherical shape, increase height, decrease particles membrane confirmed be related apoptosis treatment water extract (PLWE). Moreover, small variations showed that PLWE presented high effect but low toxicity cells, which indicated potential selectivity between cancer normal cells. This work proved could used as <;i>potential candidate<;/i> for treatments.